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Sridhar, N.
- Evaluation of anthelmintic activity of Eichhornia crassipes ischolar_mains
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PDF Views:2
Authors
Affiliations
1 KLR Pharmacy College, Paloncha, Khammam, Andhra Pradesh, IN
2 Koringa College of Pharmacy, Korangi-533 461, E.G. Dt., Andhra Pradesh, IN
3 Pydah College of Pharmacy, Patavala, E.G.Dt., Andhra Pradesh, IN
1 KLR Pharmacy College, Paloncha, Khammam, Andhra Pradesh, IN
2 Koringa College of Pharmacy, Korangi-533 461, E.G. Dt., Andhra Pradesh, IN
3 Pydah College of Pharmacy, Patavala, E.G.Dt., Andhra Pradesh, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 5, No 3 (2013), Pagination: 183-184Abstract
Herbal medicine is having very old history. Plants are the typical manufacturers of complex drug molecules, which serve as a prototype to develop more effective and less toxic medicines. Helminth infections are distressing huge population in the world. These infections are contributing to the disorders like pneumonia, anaemia, eosinophilia and under nourishment. Anthelmintics are the drugs which expels the parasitic worms from the gastrointestinal tract by either paralyzing or killing the worms. So, there is a need of investigation of new anthelmintic molecules. Eichhornia crassipes belongs to the family Pontederiaceae, commonly known as "Water hyacinth" is selected as test drug based on ethno-botanical survey conducted in East Godavari Dist., Andhra Pradesh. In present study evaluation of anthelmintic activity of ischolar_main extracts was done by using adult Indian earth worm Pheritima posthuma. The above activity was carried out using the petroleum ether, ethanol extracts of different concentrations using piperazine citrate positive control and normal saline as negative control. Overall anthelmintic activity revealed that concentration dependent nature of extracts. The extract shows potent and significant anthelmintic activity as compared to the standards and it was investigated to be used as effective anthelmintic drug.Keywords
Helminth Infections, Anthelmintics, Eichhornia crassipes, Pheritima posthuma, Petroleum Ether & Ethanol Extract
References
- Bundy DA. Immunoepidemiology of intestinal helminthic infection: The global burden of intestinal nematode disease. Trans Royal Soc Trop Med Hyg 1994; 8: 259-61.
- k.d. tripathi; Essentials of medicinal pharmacology , 6th edition, 808.
- Van Riet et al. Chronic helminth infections induce immuno modulation: consequences and mechanisms Immunobiology, 2007, 212(6):475-9
- V. J. Theodorides et al., Anthelmintic Activity of Albendazole against Liver Flukes, Tapeworms, Lung and Gastrointestinal Roundworms.
- Kushwaha and Aind; Anthelmintic activity of polyherbal preparations, international journel of pharmacy and life sciences, May, 2010; 35-37
- Shanab SM, Shalaby EA, Lightfoot DA, El-Shemy HA. Allelopathic effects of water hyacinth [Eichhornia crassipes]. PLoS One 2010; 5:13200.
- El-Shemy HA, Aboul-Enein AM, Aboul-Enein KM, jita K. Willow leaves’ extracts contain anti-tumor agents effective against three cell types. PLoS One 2007; 2:178.
- Thorn G.M, Harrison‘s Principles of internal Medicine, 1977, Mc Grew Hill, New York.
- AA Kale et al; JP Salvekara. J. Chem. Pharm. Res., 2011, 3(2), 298-302.Y Shivhare et al J. Chem. Pharm. Res., 2011, 3(1), 488-491.
- Comparative Anthelmintic Evaluation of Glycosmis mauritiana and Pedalium murex L. Roots
Abstract Views :483 |
PDF Views:0
Authors
N. Sridhar
1,
B. V. V. S. Surya Kiran
1,
M. Raghavendra
1,
M. N. V. Prasad
1,
L. K. Kanthal
1,
K. Satyavathi
1
Affiliations
1 Koringa College of Pharmacy, Korangi-533 461, E.G. Dt., Andhra Pradesh, IN
1 Koringa College of Pharmacy, Korangi-533 461, E.G. Dt., Andhra Pradesh, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 3 (2012), Pagination: 185-187Abstract
Herbal medicine is having very old history. Plants are the typical manufacturers of complex drug molecules, which serve as a prototype to develop more effective and less toxic medicines. Helminth infections are distressing huge population in the world. These infections are contributing to the disorders like pneumonia, anaemia, eosinophilia and under nourishment. Currently available anthelmintic drugs require improved management, high cost and also worms developing resistance to these drugs. So, there is a need of investigation of new anthelmintic molecules. Glycosmis mauritiana (Rutaceae) and Pedalium murex (Pedaliceae) are selected as test drugs based on ethno-botanical survey conducted in East Godavari Dist., Andhra Pradesh. The ischolar_mains of each plant were extracted with petroleum ether and ethanol. The anthelmintic activity of these extracts was screened by taking Indian earthworm (Pheretima posthuma) as a test organism and albendazole and piperazine citrate were used as reference standards. All the extracts show significant anthelmintic activity. The ethanolic extract of Glycosmis mauritiana shows more activity comparing to the other extracts. Overall anthelmintic activity revealed that concentration dependent nature of extracts. The extract shows potent and significant anthelmintic activity as compared to the standards and it was investigated to be used as effective anthelmintic drug.Keywords
Anthelmintic Activity, Glycosmis mauritiana, Pedalium murex, Indian Earthworm, Ethanolic Extract.References
- K.D. Tripathi; Essentials of Medicinal Pharmacology , 6th edition, 808.
- Van Riet et al. Chronic helminth infections induce immuno modulation: consequences and mechanisms Immunobiology, 2007, 212(6):475-9
- V. J. Theodorides et al., Anthelmintic Activity of Albendazole against Liver Flukes, Tapeworms, Lung and Gastrointestinal Roundworms.
- Kushwaha and Aind; Anthelmintic activity of polyherbal preparations, international journel of pharmacy and life sciences, May, 2010; 35-37.
- Thorn G.M, Harrison's Principles of internal Medicine, 1977, Mc Grew Hill, New York.
- AA Kale et al; JP Salvekara. J. Chem. Pharm. Res., 2011, 3(2), 298-302.
- Y Shivhare et al J. Chem. Pharm. Res., 2011, 3(1), 488-491.
- M. Sermakkani and V. Thangapandian, phytochemical screening for active compounds in Pedalium murex; Recent Research in Science and Technology 2010, 2(1): 110-114
- Trapti Rastogi et al.; Comparative Studies on Anthelmintic Activity of Moringa Oleifera and Vitex Negundo; Asian J. Research Chem. 2(2): April.-June, 2009
- Tekeshwar Kumar, Investigation of in-vitro anthelmintic activity of Bauhinia racemosa linn.; Journal of Applied Pharmaceutical Science 01 (02); 2011: 73-75
- H. K. Sundeep Kumar et al., Evaluation of Anthelmintic Activity of Pistia stratiotes Linn., Journal of Basic and Clinical Pharmacy; 103- 105
- Mali RG and Mahale NB, Evaluation of Rhynchosia minima (Linn.) DC Leaves for Anthelmintic Activity International Journal of Pharmaceutical Sciences and Nanotechnology Volume 1, Issue 2, July - September 2008.